Key result
Anticoagulation options in percutaneous coronary intervention have expanded beyond unfractionated heparin to include direct thrombin inhibitors, low-molecular-weight heparins, and Factor X inhibitors.
The availability of multiple anticoagulation options, including direct thrombin inhibitors, low-molecular-weight heparin, and Factor X inhibitors, allows for a tailored approach to anticoagulation during percutaneous coronary intervention.
Expanded anticoagulation options enable tailored PCI regimens; leaves open optimal agent selection by patient profile.
Balancing safety and efficacy of anticoagulation strategies is a fundamental goal in the performance of percutaneous coronary interventions. The ideal anticoagulant in the catheterization laboratory should effectively prevent thrombosis, yield a low bleeding risk, be titratable to individual clinical needs, be reversible when clinically indicated and be administered without the need for complicated infusions or routine monitoring. Despite its many drawbacks, unfractionated heparin continues to be the most commonly used anticoagulant in percutaneous coronary intervention. Nevertheless, anticoagulation options in the catheterization laboratory have grown substantially over the past 20 years and now include direct thrombin inhibitors, low-molecular-weight heparin molecules and Factor X inhibitors. Additional options are anticipated in the near future with novel agents targeting upstream factors in the coagulation cascade. The availability of multiple anticoagulation options allows for a tailored approach bas...
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O’Neill et al. (2010) conducted a review in Percutaneous coronary intervention. Anticoagulation strategies was evaluated. Anticoagulation options in percutaneous coronary intervention have expanded beyond unfractionated heparin to include direct thrombin inhibitors, low-molecular-weight heparins, and Factor X inhibitors.
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