Key result
Pretreatment with corticosteroids significantly increased the risk of recurrent pericarditis following colchicine therapy (OR 6.68) compared to no prior corticosteroid use.
Why the study?
Does pretreatment with corticosteroids attenuate the efficacy of colchicine in preventing recurrent pericarditis in patients with at least two prior relapses?
Population
119 patients treated with colchicine after at least two relapses of pericarditis, aggregated from European…
Comparison
Colchicine therapy vs Previous corticosteroid treatment versus no…
Design
Cohort
Authors
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Corticosteroid pretreatment may raise recurrence risk despite colchicine; leaves open whether steroids attenuate efficacy in relapsing pericarditis.
Cohort (n=119)
Yes
Does pretreatment with corticosteroids attenuate the efficacy of colchicine in preventing recurrent pericarditis in patients with at least two prior relapses?
Odds Ratio: 6.68 (95% CI 1.65–27.02)
Absolute Event Rate: 43% vs 13%
p-value: p=0.008
Pretreatment with corticosteroids significantly increases the risk of recurrent pericarditis in patients subsequently treated with colchicine.
Artom et al. (2005) conducted a cohort in Recurrent pericarditis (n=119). Previous corticosteroid therapy vs. No previous corticosteroid therapy was evaluated on Recurrence of pericarditis following colchicine therapy (OR 6.68, 95% CI 1.65-27.02, p=0.008). Pretreatment with corticosteroids significantly increased the risk of recurrent pericarditis following colchicine therapy (OR 6.68) compared to no prior corticosteroid use.
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