Key result
Colchicine administration (1 mg/day) led to complete regression of large pericardial effusions within 1 week to 1 month in two patients who had failed prior NSAID or corticosteroid therapy.
Why the study?
Does colchicine improve large pericardial effusion in patients with idiopathic pericarditis refractory to standard therapy?
Population
2 patients with large pericardial effusions complicating idiopathic pericarditis, refractory to standard…
Design
Case_series
Follow-up
24 months and 6 months
Authors
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May warrant colchicine trial in refractory cases; hypothesis-generating and requires prospective validation.
Case Report (n=2)
Does colchicine improve large pericardial effusion in patients with idiopathic pericarditis refractory to standard therapy?
Colchicine may be an effective treatment for large pericardial effusions complicating idiopathic pericarditis when NSAIDs or corticosteroids fail.
Adler et al. (1998) conducted a case report in large pericardial effusion complicating idiopathic pericarditis (n=2). Colchicine was evaluated on complete regression of the pericardial effusion on echocardiography. Colchicine administration (1 mg/day) led to complete regression of large pericardial effusions within 1 week to 1 month in two patients who had failed prior NSAID or corticosteroid therapy.
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