Key result
Congestive heart failure is associated with an elevated cardiac troponin I level in non-acute coronary syndrome patients with chronic kidney disease.
Why the study?
What are the risk factors for elevated cTnI in non-ACS patients with chronic kidney disease?
Observational (n=293)
No
What are the risk factors for elevated cTnI in non-ACS patients with chronic kidney disease?
In non-ACS patients with CKD, elevated cTnI is common and independently associated with congestive heart failure, suggesting it reflects underlying myocardial injury rather than solely decreased renal clearance.
Answers are grounded in this paper and cite their sources.
May indicate HF-related injury in non-ACS CKD; leaves open whether troponin thresholds require adjustment.
OBJECTIVE: The aim of this study was to assess the results of troponin I (cTnI) in non- acute Coronary Syndrome (ACS) patients with chronic kidney disease (CKD). We also examined the risk factors for elevated cTnI in non-ACS patients with CKD and whether stage 5 CKD modifies the associations of elevated cTnI and the risk factors in non-ACS patients with CKD. METHODS: A retrospective study was performed. Logistic regression models were used. RESULTS: 293 non-ACS patients with CKD were included in the current study. 43.34% non-ACS patients with CKD have an elevated cTnI level and 5.12% have an elevated cTnT level in MI range. In CKD patients without ACS and heart failure, only 26.03% (38/146) patients have an elevated cTnT level. In adjusted analyses, age, diastolic blood pressure and congestive heart failure is associated with an elevated cTnI level in non-ACS patients with CKD. Congestive heart failure is associated with an elevated cTnI level in non-ACS patients with CKD (OR 2.30, 95% CI 1.08,4.88, P=0.03). Stage 5 CKD does not modify the association of congestive heart failure and an elevated cTnI level. CONCLUSION: 43.34% non-ACS patients with CKD and 26.03% CKD patients without ACS and congestive heart failure have an elevated cTnI level. Congestive heart failure is associated with an elevated cTnI level in non-ACS patients with CKD. Stage 5 CKD does not modify the association of congestive heart failure and an elevated cTnI level.
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Chen et al. (2013) conducted an observational in Non-acute coronary syndrome with chronic kidney disease (n=293). Congestive heart failure vs. No congestive heart failure was evaluated on Elevated cTnI level (> 0.06 ng/ml) (OR 2.30, 95% CI 1.08-4.88, p=0.03). Congestive heart failure is associated with an elevated cardiac troponin I level in non-acute coronary syndrome patients with chronic kidney disease.
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