Key result
A proposed model of the human cardiovascular system with a loop for autonomic control of mean arterial pressure produced signals qualitatively and quantitatively similar to experimental signals.
A computational model incorporating nonlinearity and an autonomic control loop successfully simulates human cardiovascular signals and respiratory synchronization.
Answers are grounded in this paper and cite their sources.
May inform in silico testing of autonomic regulation; leaves open clinical validation and translation.
We proposed a model of human cardiovascular system that describes the cardiac cycle, the autonomic regulation of heart and vessels, the baroreflex, and the formation of arterial pressure. The model also makes allowance for the influence of respiration on these processes. It was found that an allowance for nonlinearity and insertion of a loop for the autonomic control of mean arterial pressure (having the form of self oscillating time-delay system) enables to obtain model signals with statistical and spectral characteristics that are qualitatively and quantitatively similar to.those for experimental signals. The model reproduces the phenomenon of synchronization of the loop for mean arterial pressure regulation with a basic frequency of approximately 10 s by the signal of respiration.
No takes yet. Share an insight, caveat, or question.
Karavaev et al. (2017) studied this question. Computational model of the human cardiovascular system was evaluated on Statistical and spectral characteristics of model signals. A proposed model of the human cardiovascular system with a loop for autonomic control of mean arterial pressure produced signals qualitatively and quantitatively similar to experimental signals.
Synapse has enriched 10 related papers. Consider them for comparative context: