Key result
Higher Framingham 10-year CHD risk scores correlated with a higher incidence of asymptomatic coronary heart disease, with 31.37% of patients showing a positive treadmill test.
Why the study?
Does the Framingham 10-year CHD risk score correlate with asymptomatic coronary heart disease detected by treadmill testing in type 2 diabetics?
Cross-Sectional (n=102)
Does the Framingham 10-year CHD risk score correlate with asymptomatic coronary heart disease detected by treadmill testing in type 2 diabetics?
The Framingham 10-year CHD risk score correlates strongly with asymptomatic coronary heart disease detected by treadmill testing in North Indian patients with type 2 diabetes.
May support Framingham stratification for asymptomatic CHD detection in type 2 diabetes; leaves open need for prospective outcome trials.
Background and objectives: Coronary Heart Disease (CHD) has a high prevalence in Asian Indians & is the leading cause of morbidity & mortality in patients with type 2 diabetes due to silent myocardial ischemia. This needs early cardio vascular assessment through non invasive tests e.g. Treadmill Test (TMT) & Framingham 10-year CHD risk in addition to periodical clinical examination & resting electrocardiogram. Methods: 102 known north Indian diabetics without clinical & electrocardiographic evidence of CHD were evaluated for smoking, blood pressure, glycosylated hemoglobin, fasting & post-prandial blood sugar & lipid profile to calculate Framingham score system for 10-year CHD risk assessment along with exercise treadmill test. Results: Among 102 diabetic patients, TMT was positive in 32 (31.37%) patients; more in males (59.73%). Mean cholesterol (189.81 mg %), triglycerides (135.19 mg %) and LDL (116.28 mg %) levels were significantly high in TMT positive cases (P 20%), 28 intermediate (≥10-19.9%) & 51 low ( Conclusion: A 6-fold higher incidence between low & intermediate, 2.4-fold between intermediate & high and 14-fold between low & high Framingham 10-year CHD risk groups is suggestive of higher incidence of TMT positive cases correlates with higher Framingham 10-year CHD risk & are more prone for asymptomatic CHD in north Indian diabetics.
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Gupta et al. (2015) conducted a cross-sectional in Type 2 diabetes without clinical and electrocardiographic evidence of coronary heart disease (n=102). Framingham 10-year CHD risk score vs. Low Framingham 10-year CHD risk score was evaluated on Treadmill test (TMT) positivity. Higher Framingham 10-year CHD risk scores correlated with a higher incidence of asymptomatic coronary heart disease, with 31.37% of patients showing a positive treadmill test.
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