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October 1, 1996AJP Heart and Circulatory Physiology

Slowing of carotid-cardiac baroreflex with standing and with isometric and dynamic muscle activity

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Key result

Conditions with increased sympathetic activity significantly slowed the carotid-cardiac baroreflex bradycardic response compared to supine rest (2-3 s vs <1 s).

Why the study?

Does concurrent sympathetic stimulation (standing, exercise) slow the carotid-cardiac baroreflex in male subjects?

Population

6 male subjects

Comparison

10-s trains of 50-mmHg pulses of neck suction… vs Supine rest

Design

Other

Authors

PSPatrik SundbladKarolinska University HospitalDLDag LinnarssonKarolinska Institutet

Discussion

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Implication

Clinicians should account for sympathetic effects in baroreflex assessment; extends physiological data but leaves clinical relevance open.

Study Design

Type

Observational (n=6)

Structured PICO

Does concurrent sympathetic stimulation (standing, exercise) slow the carotid-cardiac baroreflex in male subjects?

P
Population
6 male subjects evaluated during supine rest, upright rest, isometric arm exercise, and dynamic leg exercise.
E
Exposure
10-s trains of 50-mmHg pulses of neck suction (NS) during upright rest, isometric arm exercise at 30% of maximum voluntary contraction, and dynamic leg exercise at 100 W in the sitting position
C
Comparator
Supine rest
O
Outcome
Time to full bradycardic responsesurrogate

The carotid-cardiac baroreflex in humans is slowed under conditions of concurrent sympathetic stimulation such as standing or exercise.

Cite This Study

Sundblad et al. (1996) reported an observational. Conditions with increased sympathetic activity (upright rest, isometric arm exercise, dynamic leg exercise) vs. Supine rest was evaluated on Time for full bradycardic response to develop. Conditions with increased sympathetic activity significantly slowed the carotid-cardiac baroreflex bradycardic response compared to supine rest (2-3 s vs <1 s).

synapsesocial.com/papers/6a1f1ae6e800cc4eef5529d0https://doi.org/10.1152/ajpheart.1996.271.4.h1363
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Effect of dynamic exercise on human carotid-cardiac baroreflex latency1995 · 31 citations
  2. 2Carotid Baroreceptor Reflexes in Humans During Orthostatic Stress2001 · 80 citations
  3. 3Modulation of arterial baroreflex dynamic response during mild orthostatic stress in humans2004 · 30 citations
  4. 4Carotid baroreflex responsiveness during dynamic exercise in humans1993 · 279 citations
  5. 5Cardiovascular responses to carotid sinus baroreceptor stimulation during moderate to severe exercise in man1990 · 53 citations