Key result
Depression symptoms measured at 1-year post-CABG were associated with increased 14-year mortality (HR 1.27; 95% CI 1.02–1.59), whereas baseline measures were not significant predictors.
Why the study?
It was unclear when post-CABG psychosocial factors best predict outcomes, whether they interact, or if findings differ between men and women.
Do psychosocial factors measured post-CABG predict long-term mortality and morbidity in male and female CABG recipients?
Observational (n=296)
Do psychosocial factors measured post-CABG predict long-term mortality and morbidity in male and female CABG recipients?
Answers are grounded in this paper and cite their sources.
Depression and household responsibility measured at 1-year post-CABG, but not immediately post-procedure, are significant predictors of long-term mortality and event recurrence.
Background Psychosocial factors may influence mortality and morbidity after coronary bypass surgery (CABG), but it is unclear when, post-surgery, they best predict the outcome, if they interact, or whether results differ for men and women. Methods This prospective, observational study assessed depression symptoms, social support, marital status, household responsibility, functional impairment, mortality and need for further coronary procedures over 14 years of follow-up. Data were collected in-hospital post-CABG and at home 1-year later. Mortality and subsequent cardiac procedure data were extracted from a Cardiac Registry. Results Of 296 baseline participants, 78% (43% were women) completed data at 1-year post-CABG. Long-term survival was shorter with 1-year depression and lower household responsibility but that was not true for the measures taken at baseline [HR for depression = 1.27; 95% CI 1.02–1.59 v. 0.99 (0.78–1.25), and HR = 0.71; 95% CI 0.52–0.97 v. 0.97 (0.80–1.16)] for household responsibility. An interaction between depression symptoms and social support at year 1 [χ 2 (11) = 111.05, p < 0.001] revealed a greater hazard of mortality d with increased depression only at mean (HR = 1.67; 95% CI 1.21–2.26) and high social support (HR = 2.23; 95% CI 1.46–3.40). Depression also accounted for increased event recurrence. There were no significant interactions of sex with medical long-term outcomes. Conclusions In a sex-balanced sample, depression and household responsibility measured at 1-year post-CABG were associated with significant variance in unadjusted and adjusted predictor models of long-term mortality whereas the same indices determined right after the procedure were not significant predictors.
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Linden et al. (2021) conducted an observational in Coronary artery bypass graft (CABG) (n=296). Depression symptoms at 1-year post-CABG vs. Baseline depression symptoms / lower depression symptoms was evaluated on Long-term mortality (HR 1.27, 95% CI 1.02-1.59). Depression symptoms measured at 1-year post-CABG were associated with increased 14-year mortality (HR 1.27; 95% CI 1.02–1.59), whereas baseline measures were not significant predictors.
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