A candidate locus in the renalase gene and susceptibility to blood pressure responses to the dietary salt

Figures

• 

  FIGURE 1. Manhattan plot for genome-wide association study of salt sensitivity of blood pressure in a white population. This plot is based on log10 (P value) from genome-wide association study and imputation analysis against chromosome position. The lower line indicates a suggestive association threshold, P < 1 × 10−5; the upper line indicates a genome-wide significance threshold, P < 5 × 10−8. GWAS, genome-wide association study; SNP, single nucleotide polymorphism; SSBP, salt sensitivity of blood pressure.

• 

  FIGURE 2. Regional association plots for locus significantly associated with salt sensitivity of blood pressure in a white population on chromosome 10q23.33 of the renalase gene. The regional association plot was generated from the associated data of a genome-wide association study with LocusZoom. Dark gray lines represent local recombination rates. Single nucleotide polymorphisms are grayed according to their linkage disequilibrium (measured by r2) with the marker single nucleotide polymorphism. Diamonds (rs10887801) represent the most significantly associated single nucleotide polymorphism in this region in the genome-wide association study. The single nucleotide polymorphism position is based on NCBI build 37.

• 

  FIGURE 3. Haplotype block for top eight single nucleotide polymorphisms of renalase gene associated with salt-sensitive blood pressure in a white cohort. (pairwise linkage disequilibrium coefficients D′ × 100 are shown in each cell (D′ values. of 1.0 are not shown). The r2 color scheme of Haploview was applied (r2 = 0 shown in white, 0 < r2 < 1 shown in shades of gray, and r2 > 0.95 close to 1 shown in black). BP1, position of the first single nucleotide polymorphism in the block; BP2, position of the last single nucleotide polymorphism in the block; HAP, haplotype; LIB, liberal salt; SNP, single nucleotide polymorphism; SSBP, salt-sensitive blood pressure.

• 

  FIGURE 4. Haplotype block analysis for seven single nucleotide polymorphisms of the renalase gene associated with SBP on a liberal salt diet in a white cohort. BP1, position of the first single nucleotide polymorphism in the block; BP2, position of the last single nucleotide polymorphism in the block; LIB, liberal salt; SNP, single nucleotide polymorphism.