Key result
The CYBA/rs4673-A allele was significantly associated with a 1.652 mmHg decrease in systolic blood pressure during diuresis shrinkage, highlighting genetic susceptibility to salt sensitivity.
Why the study?
Genetic susceptibility to salt sensitivity of blood pressure needed verification in varied and large sample populations, along with estimation of interactions with potential risk factors.
Do candidate gene polymorphisms influence the susceptibility to salt sensitivity of blood pressure in a Han Chinese population?
Cross-Sectional (n=2,057)
Yes
Do candidate gene polymorphisms influence the susceptibility to salt sensitivity of blood pressure in a Han Chinese population?
Mean Difference: -1.652 (95% CI -2.514–-0.789)
p-value: p=1.80E-04
Genetic variants in PRKG1, CYP4A11, and CYBA are significantly associated with salt sensitivity of blood pressure in a Han Chinese population, suggesting a genetic predisposition that may be mediated by other risk factors.
May inform salt-sensitivity risk stratification in Han Chinese; leaves open validation and clinical utility.
Genome-wide association studies suggest that there is a significant genetic susceptibility to salt sensitivity of blood pressure (SSBP), but it still needs to be verified in varied and large sample populations. We attempted to verify the associations between single-nucleotide polymorphisms (SNPs) in candidate genes and SSBP and to estimate their interaction with potential risk factors. A total of 29 candidate SNPs were genotyped in the 2,057 northern Han Chinese population from the Systems Epidemiology Study on Salt Sensitivity. A modified Sullivan’s acute oral saline load and diuresis shrinkage test (MSAOSL-DST) was used to identify SSBP. A generalized linear model was conducted to analyze the association between SNPs and SSBP, and Bonferroni correction was used for multiple testing. Mediation analysis was utilized to explore the mediation effect of risk factors. Eleven SNPs in eight genes (PRKG1, CYBA, BCAT1, SLC8A1, AGTR1, SELE, CYP4A11, and VSNL1) were identified to be significantly associated with one or more SSBP phenotypes ( P < 0.05). Four SNPs (PRKG1/rs1904694 and rs7897633, CYP4A11/rs1126742, and CYBA/rs4673) were still significantly associated after Bonferroni correction ( P < 0.0007) adjusted for age, sex, fasting blood glucose, total cholesterol, salt-eating habit, physical activity, and hypertension. Stratified analysis showed that CYBA/rs4673 was significantly associated with SSBP in hypertensive subjects ( P < 0.0015) and CYP4A11/rs1126742 was significantly associated with SSBP in normotensive subjects ( P < 0.0015). Subjects carrying both CYBA/rs4673-AA and AGTR1/rs2638360-GG alleles have a higher genetic predisposition to salt sensitivity due to the potential gene co-expression interaction. Expression quantitative trait loci analysis (eQTL) suggested that the above positive four SNPs showed cis-eQTL effects on the gene expression levels. Mediation analysis suggested that several risk factors were mediators of the relation between SNP and SSBP. This study suggests that the genetic variants in eight genes might contribute to the susceptibility to SSBP, and other risk factors may be the mediators.
No takes yet. Share an insight, caveat, or question.
Xie et al. (2021) conducted a cross-sectional in Salt sensitivity of blood pressure (n=2,057). Candidate gene single-nucleotide polymorphisms (e.g., CYBA/rs4673) vs. Reference genotypes was evaluated on Change in systolic blood pressure during diuresis shrinkage (CYBA/rs4673-A allele, additive model) (MD -1.652, 95% CI -2.514 to -0.789, p=1.80E-04). The CYBA/rs4673-A allele was significantly associated with a 1.652 mmHg decrease in systolic blood pressure during diuresis shrinkage, highlighting genetic susceptibility to salt sensitivity.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: