Key result
Chronic inflammation is linked to the interconnected pathogenesis of NAFLD and T2DM.
Why the study?
With the increasing prevalence of NAFLD and DM2, improved prevention, treatment, and detection are needed, prompting an examination of chronic inflammation as a potential pathogenic link.
Chronic inflammation plays a crucial role in the interconnected pathogenesis of NAFLD and type 2 diabetes mellitus, highlighting potential new targets for prevention and treatment.
Answers are grounded in this paper and cite their sources.
May inform anti-inflammatory strategies in NAFLD with type 2 diabetes; leaves open validation in prospective trials before practice change.
The prevalence of metabolic-related disorders, such as non-alcoholic fatty liver disease (NAFLD) and type 2 diabetes mellitus (DM2), has been increasing. Therefore, developing improved methods for the prevention, treatment, and detection of these two conditions is also necessary. In this study, our primary focus was on examining the role of chronic inflammation as a potential link in the pathogenesis of these diseases and their interconnections. A comprehensive search of the PubMed database using keywords such as "non-alcoholic fatty liver disease", "type 2 diabetes mellitus", "chronic inflammation", "pathogenesis", and "progression" yielded 177 relevant papers for our analysis. The findings of our study revealed intricate relationships between the pathogenesis of NAFLD and DM2, emphasizing the crucial role of inflammatory processes. These connections involve various molecular functions, including altered signaling pathways, patterns of gene methylation, the expression of related peptides, and up- and downregulation of several genes. Our study is a foundational platform for future research into the intricate relationship between NAFLD and DM2, allowing for a better understanding of the underlying mechanisms and the potential for introducing new treatment standards.
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Frankowski et al. (2023) conducted a review in Non-alcoholic fatty liver disease (NAFLD) and type 2 diabetes mellitus (DM2). Chronic inflammation was evaluated on Role of chronic inflammation in the pathogenesis and interconnections of NAFLD and DM2. A review of 177 papers highlighted the crucial role of chronic inflammatory processes and molecular functions in the interconnected pathogenesis of NAFLD and type 2 diabetes mellitus.
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