Key result
Calcium antagonists and amiodarone are the most effective medical therapies for hypertrophic cardiomyopathy, with surgical treatment considered for patients who show no improvement.
Medical therapy with calcium antagonists and amiodarone is effective for managing hypertrophic cardiomyopathy, with surgical options reserved for refractory cases.
May guide therapy selection in hypertrophic cardiomyopathy; leaves open need for randomized trials to validate efficacy and timing.
Therapy of hypertrophic cardiomyopathy aspires to reduce symptoms, increase exercise tolerance, retard or prevent disease progression, and improve prognosis. Medical treatment with calcium antagonists and suppression of rhythm disturbances with amiodarone seem to be most effective. In patients who show no improvement, surgical treatment must be considered.
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Hopf et al. (1990) studied this question. Calcium antagonists and amiodarone are the most effective medical therapies for hypertrophic cardiomyopathy, with surgical treatment considered for patients who show no improvement.
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