Population
Isolated, blood-perfused dog hearts
Comparison
Elevation of end-diastolic pressure to levels… vs Lower end-diastolic pressures
Design
Preclinical
Authors
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Questions relevance of descending limb at extreme preload; leaves open translation to human ventricular function.
In isolated dog hearts, there is minimal loss of ventricular performance attributable to a descending limb of the Frank-Starling mechanism even at end-diastolic pressures as high as 100 mm Hg.
MONROE et al. (1970) studied this question.
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