Demonstrated negative diastolic ventricular pressures after inflow occluded ejections in an isolated canine heart model, providing insights into the mechanics of ventricular diastole.
No immediate clinical implications for diastolic assessment; extends isolated heart models of ventricular suction but leaves human relevance open.
An isolated canine heart preparation was developed which permitted evaluation of the time course of pressure and flow during ventricular diastole. Negative diastolic ventricular pressures were observed after inflow occluded ejections from a wide range of end diastolic volumes. The results are evaluated in the context of recent observations on myocardial ultrastructure and geometry and potential clinical implications are discussed.
No takes yet. Share an insight, caveat, or question.
Tyberg et al. (1970) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: