January 29, 2015Journal of Hypertension
Joint scientific statement of the European Association for the Study of Obesity and the European Society of Hypertension
Why the study?
Does the assessment of early vascular ageing (EVA) biomarkers improve cardiovascular risk assessment in obese individuals compared to traditional risk scores?
Population
Obese individuals
Comparison
Assessment of early vascular ageing biomarkers vs Traditional cardiovascular risk scores
Design
Guideline
Authors
Discussion
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Member takes
Implication
Early vascular ageing biomarkers should not yet refine risk assessment in obesity; leaves open need for standardization and large-scale validation.
Structured PICO
Does the assessment of early vascular ageing (EVA) biomarkers improve cardiovascular risk assessment in obese individuals compared to traditional risk scores?
P
Population
Obese individuals
I
Intervention
Assessment of early vascular ageing (EVA) biomarkers (arterial stiffness, central blood pressure, carotid intima-media thickness, flow-mediated vasodilation)
C
Comparator
Traditional cardiovascular risk scores
O
Outcome
Refinement of cardiovascular risk assessmentsurrogate
Early vascular ageing biomarkers have the potential to refine cardiovascular risk assessment in obesity, but require standardized methodologies and validation in large trials before routine clinical use.
Limitations
- Published studies on vascular markers in obesity and weight loss vary in quality and study design, are sometimes conducted in small populations, and use differing methodologies.
- Current vascular measurements are still crude and may not be sufficient to cover the different aspects of early vascular ageing in obesity.
- Methodologies for measurements of vascular markers need to be further standardized and less operator-dependent
- Published studies vary in quality and study design
- Sometimes conducted in small populations
- Use a variety of differing methodologies and study differing vascular beds
- Current vascular measurements are still crude
Cite This Study
Jordan et al. (2015) conducted a review in Obesity and cardiovascular risk. Assessment of early vascular ageing (EVA) biomarkers was evaluated. Assessment of early vascular ageing biomarkers may help refine cardiovascular risk assessment in obesity, though current methodologies require standardization and validation in large studies.