Key result
Six months of weight reduction and exercise significantly improved brachial artery flow-mediated dilation (12.9% vs 7.9% at baseline; P<0.001) in obese subjects with insulin resistance syndrome.
Why the study?
Does 6 months of weight reduction and exercise improve endothelial function in obese subjects with insulin resistance syndrome?
Population
24 obese subjects with insulin resistance syndrome, mean age 49.3 +/- 1.9 years, 9 men and 15 women, BMI…
Design
Cohort
Follow-up
6 months
Authors
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May improve endothelial function via lifestyle intervention in insulin resistance; leaves open confirmation in larger outcome trials.
Does 6 months of weight reduction and exercise improve endothelial function in obese subjects with insulin resistance syndrome?
Absolute Event Rate: 12.9% vs 7.9%
p-value: p=<0.001
A 6-month lifestyle modification program of weight reduction and exercise significantly improves macrovascular endothelial function and reduces markers of endothelial activation in obese subjects with insulin resistance syndrome.
Hamdy et al. (2003) studied Obesity with insulin resistance syndrome (IRS) (n=24). Weight reduction and exercise vs. Baseline was evaluated on Brachial artery flow-mediated dilation (FMD) (p=<0.001). Six months of weight reduction and exercise significantly improved brachial artery flow-mediated dilation (12.9% vs 7.9% at baseline; P<0.001) in obese subjects with insulin resistance syndrome.
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