What question did this study set out to answer?

To determine whether maternal smoking during pregnancy is associated with adult-onset asthma and compromised lung function in offspring up to age 46 years.

April 27, 2020European Respiratory JournalOpen Access

Maternal smoking during pregnancy affects adult onset of asthma in offspring: a follow up from birth to age 46 years

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Authors

STSanna Toppila‐SalmiUniversity of Helsinki ALAnnika LuukkainenUniversity of Helsinki BXBaizhuang XuCentral South University

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Implication

Birth cohort study finds prenatal smoke exposure increases adult-onset asthma risk in adult offspring, indicating lifelong respiratory vulnerability from maternal smoking.

Key Points

To determine whether maternal smoking during pregnancy is associated with adult-onset asthma and compromised lung function in offspring up to age 46 years.
Analyzed clinical and questionnaire data from 5,200 individuals free of physician-diagnosed asthma at 31 years of age in the Northern Finland Birth Cohort 1966 Study followed to age 46 years.
Evaluated maternal smoking in the final trimester of pregnancy against offspring spirometry (FEV1/FVC ratio) and incident physician-diagnosed asthma using adjusted multivariate regression analyses.
Cumulative incidence of physician-diagnosed asthma between ages 31 and 46 was 5.1% in men and 8.8% in women, with gestational smoke exposure significantly increasing adult-onset asthma risk (adjusted OR 1.54, 95% CI 1.04–2.29).
Risk was higher among offspring with prior non-diagnosed asthma (OR 9.63, 95% CI 2.28–40.67), prior cough with wheeze (OR 3.21, 95% CI 1.71–6.05), or the RUNX1 rs11702779-AA haplotype (OR 5.53, 95% CI 2.11–14.52; interaction p=0.10).
Gestational smoke exposure was significantly associated with a reduced FEV1/FVC ratio in offspring measured at 31 years of age.

Cite This Study

Toppila‐Salmi et al. (2020) studied this question.

synapsesocial.com/papers/6a1f35852865985bbe2a956e https://doi.org/10.1183/13993003.01857-2019

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Implication

Birth cohort study finds prenatal smoke exposure increases adult-onset asthma risk in adult offspring, indicating lifelong respiratory vulnerability from maternal smoking.

Maternal smoking during pregnancy affects adult onset of asthma in offspring: a follow up from birth to age 46 years

Discussion

Member takes

Implication

Key Points

Cite This Study

Maternal smoking during pregnancy affects adult onset of asthma in offspring: a follow up from birth to age 46 years

Discussion

Member takes

Implication

Key Points

Cite This Study

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