Inhibiting glycolysis and oxidative phosphorylation to reduce platelet energy potential resulted in the inhibition of clot retraction, adhesion, and aggregation.
Reducing the energy potential of blood platelets inhibits their ability to retract clots, adhere, and aggregate.
Absolute Event Rate: 0% vs 0%
Glycolysis was inhibited by deoxy-D-glucose and oxidative phosphorylation by means of either antimycin or oligomycin to reduce the energy potential of blood platelets. This resulted in inhibition of clot retraction and of adhesion and aggregation of platelets.
Murer et al. (Sun,) reported a other. Inhibiting glycolysis and oxidative phosphorylation to reduce platelet energy potential resulted in the inhibition of clot retraction, adhesion, and aggregation.