Why the study?
The role of mitochondria in platelet adhesion, activation, and thrombus formation under blood flow conditions remains to be elucidated.
Mitochondrial function is necessary for platelet activation via rapid intracellular calcium increase upon VWF adhesion, but does not influence platelet adhesion or 3-dimensional thrombus growth on collagen fibrils.
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Should not yet alter antiplatelet strategies; leaves open distinct mitochondrial roles in platelet activation versus thrombus formation.
Tamura et al. (2022) studied this question.
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