Key result
Pediatric patients with congenital heart disease and perinatal neurological antecedents had significantly higher pre-operative serum concentrations of S100β protein compared to those without such history (0.0188 vs 0.0155 ug/L, p=0.019).
Why the study?
Does preoperative serum S100B protein correlate with brain damage and oxidative stress in pediatric patients with congenital heart disease?
Observational (n=72)
Does preoperative serum S100B protein correlate with brain damage and oxidative stress in pediatric patients with congenital heart disease?
Preoperative serum S100B protein, when complemented with total antioxidant capacity, may serve as a potential biomarker for brain damage in pediatric patients with congenital heart disease.
Answers are grounded in this paper and cite their sources.
May signal prior neurological injury in congenital heart disease; leaves open validation as a preoperative biomarker.
Objective: S100B protein has been implicated as a biomarker of brain injury in several clinical conditions. The aim of this study is to determine and to correlate concentrations of the protein within preoperative conditions in pediatric population with congenital heart disease: with perinatal suffering, neurological pathological antecedents, arterial O 2 saturation and oxidative stress parameters values.
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Luis Antonio Pando-Orellana (2018) conducted an observational in Congenital heart disease (n=72). Perinatal neurological antecedents vs. No perinatal neurological antecedents was evaluated on Pre-operative serum concentration of S100β protein (ug/L) (p=0.019). Pediatric patients with congenital heart disease and perinatal neurological antecedents had significantly higher pre-operative serum concentrations of S100β protein compared to those without such history (0.0188 vs 0.0155 ug/L, p=0.019).
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