What question did this study set out to answer?

To examine ventilatory physiology and panic susceptibility in response to respiratory challenges and chemical panicogens across diagnostic groups.

January 1, 1988Archives of General Psychiatry

Ventilatory Physiology of Patients With Panic Disorder

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Authors

JGJack M. GormanUniversity of Pisa

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Implication

Comparative challenge study reveals exaggerated ventilatory responses to carbon dioxide in panic disorder, suggesting hypersensitive respiratory receptors trigger panic attacks.

Key Points

To examine ventilatory physiology and panic susceptibility in response to respiratory challenges and chemical panicogens across diagnostic groups.
Assessed 31 patients with DSM-III panic disorder or agoraphobia with panic attacks, 12 patients with other anxiety disorders, and 13 normal controls.
Conducted physiological challenges consisting of room air hyperventilation, 5% carbon dioxide inhalation, and intravenous sodium lactate infusion.
Panic attacks were induced in 58% of panic disorder patients with sodium lactate, 39% with 5% carbon dioxide, and 23% with room air hyperventilation.
Among non-panic anxiety controls, four panicked with sodium lactate, one with hyperventilation, and none with carbon dioxide; only one normal control panicked with sodium lactate and carbon dioxide.
Carbon dioxide–induced panic was specifically associated with an exaggerated ventilatory response, increased plasma norepinephrine levels, and elevated diastolic blood pressure.

Cite This Study

Jack M. Gorman (1988) studied this question.

synapsesocial.com/papers/6a1f437bda07783dec233cc0 https://doi.org/10.1001/archpsyc.1988.01800250035006

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Implication

Comparative challenge study reveals exaggerated ventilatory responses to carbon dioxide in panic disorder, suggesting hypersensitive respiratory receptors trigger panic attacks.

Ventilatory Physiology of Patients With Panic Disorder

Discussion

Member takes

Implication

Key Points

Cite This Study

Ventilatory Physiology of Patients With Panic Disorder

Discussion

Member takes

Implication

Key Points

Cite This Study

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