What is the clinical evidence from this study?

Study design: Cross-Sectional. Population: HIV infection and High Blood Pressure (n=1045). Intervention: Older age (18-25 years) vs. Younger age (13-17 years). Primary outcome: High blood pressure (elevated BP or hypertension) (aPR 1.21, 95% CI 1.01-1.44, p=0.035).

January 1, 2023Clinical HypertensionOpen Access

High blood pressure and associated factors among HIV-infected young persons aged 13 to 25 years at selected health facilities in Rwenzori region, western Uganda, September–October 2021

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Key result

Among HIV-infected young persons, the overall prevalence of high blood pressure was 49%, with older age (18-25 years) significantly increasing the prevalence by 21% (aPR 1.21) compared to younger adolescents (13-17 years).

Why the study?

High blood pressure is an emerging challenge in young persons, and the risk of cardiovascular events may be further amplified among people living with HIV.

Population

1,045 PLHIV aged 13 to 25 years at nine health facilities in western Uganda

Comparison

Factors associated with high blood pressure

Design

Cross-sectional study

Authors

RMRichard MigishaMbarara University of Science and Technology AAAlex Riolexus ArioBaylor College of Medicine Children’s Foundation DKDaniel KadoberaCenters for Disease Control and Prevention

Discussion

Member takes

Implication

High BP prevalence in HIV youth may warrant screening attention; leaves open prospective studies on outcomes and interventions.

Study Design

Type

Cross-Sectional (n=1,045)

Multicenter

Yes

Structured PICO

Population

1,045 HIV-infected adolescents and young adults aged 13 to 25 years were evaluated at a single clinic visit to determine the prevalence and risk factors for high blood pressure.

Outcome

Prevalence of high blood pressure (HBP), defined as elevated BP (<120/<80 to 129/<80 mmHg) or hypertension (≥130/80 mmHg) at a single clinic visit.surrogate

Main Result

Relative Risk: 1.21 (95% CI 1.01–1.44)

Absolute Event Rate: 52.7% vs 40.8%

p-value: p=0.035

Nearly half of HIV-infected young persons aged 13 to 25 years in western Uganda had high blood pressure, highlighting a significant and previously underrecognized cardiovascular risk in this population.

Limitations

Cross-sectional design limits the ability to draw causal inferences from the observed associations.
Utilization of a single clinic visit blood pressure reading may have led to white coat hypertension and potentially overestimated the prevalence of high blood pressure.
Did not assess secondary causes of high blood pressure, including renal diseases and endocrine disorders, potentially leading to residual confounding.
Conducted in one region of western Uganda, meaning findings may not be generalizable to other regions.
Cross-sectional design limits causal inferences from the observed associations.
Utilization of a single clinic visit BP reading may have led to 'white coat hypertension' and potentially overestimated the prevalence of HBP.
Did not assess secondary causes of HBP, including renal diseases and endocrine disorders.
Conducted in one region of western Uganda, limiting generalizability to other regions.

Cite This Study

Migisha et al. (2023) conducted a cross-sectional in HIV infection and High Blood Pressure (n=1,045). Older age (18-25 years) vs. Younger age (13-17 years) was evaluated on High blood pressure (elevated BP or hypertension) (aPR 1.21, 95% CI 1.01-1.44, p=0.035). Among HIV-infected young persons, the overall prevalence of high blood pressure was 49%, with older age (18-25 years) significantly increasing the prevalence by 21% (aPR 1.21) compared to younger adolescents (13-17 years).

synapsesocial.com/papers/6a1f438fd03d2b72e7233cb1 https://doi.org/10.1186/s40885-022-00230-5

View Full Paper

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Bookmark

High blood pressure and associated factors among HIV-infected young persons aged 13 to 25 years at selected health facilities in Rwenzori region, western Uganda, September–October 2021

Discussion

Member takes

Implication

Study Design

Structured PICO

Main Result

Limitations

Cite This Study

High blood pressure and associated factors among HIV-infected young persons aged 13 to 25 years at selected health facilities in Rwenzori region, western Uganda, September–October 2021

Discussion

Member takes

Implication

Study Design

Structured PICO

Main Result

Limitations

Cite This Study

Also Consider

Also Consider