Key result
The highest quartile of the triglyceride-glucose index was associated with a 4.14-fold increased odds of hypertension compared to the lowest quartile in adults without prior cardiovascular disease.
Why the study?
Insulin resistance contributes to hypertension and the TyG index is a simple marker of it, but its association with blood pressure elevation in a large general population without related diseases required investigation.
Does a higher TyG index predict elevated blood pressure and hypertension in normotensive subjects?
Cross-Sectional (n=15,826)
Does a higher TyG index predict elevated blood pressure and hypertension in normotensive subjects?
Odds Ratio: 4.14 (95% CI 3.4–5.02)
p-value: p=<0.001
The TyG index is strongly associated with increased blood pressure and may serve as an early predictor of hypertension risk in healthy individuals.
TyG index may flag hypertension risk in primary prevention; leaves open prospective validation before any clinical adoption.
Abstract Insulin resistance (IR) is an important contributor to the development of hypertension (HTN), and the triglyceride-glucose (TyG) index has been proposed as a simple, reliable marker of IR. This study investigated the association between the TyG index and blood pressure (BP) elevation in a large general population without a history of related diseases. The study enrolled 15,826 adults from the 2016–2019 Korea National Health and Nutrition Examination Survey (KNHANES). Participants were classified into quartiles based on the TyG index and BP was categorized as normal BP, elevated BP, pre-HTN, and HTN. The associations of the TyG index with BP categories were assessed using multivariate multinomial logistic regression models with normal BP as the reference group. The mean systolic/diastolic BP and prevalence of HTN increased with the TyG index. The continuous TyG index had a strong dose-response relationship with increased odds of elevated BP, pre-HTN, and HTN. Compared with the lowest TyG index quartile, the highest TyG index quartile was significantly associated with higher odds of having elevated BP (OR, 1.52; 95% CI, 1.23–1.87), pre-HTN (OR, 2.18; 95% CI, 1.91–2.48), and HTN (OR, 4.14; 95% CI, 3.40–5.02). Our study suggests that the TyG index is an early predictor of the risk of HTN.
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Lee et al. (2021) conducted a cross-sectional in Hypertension risk in normotensive subjects (n=15,826). Triglyceride-glucose (TyG) index vs. Lowest TyG index quartile (Q1) was evaluated on Hypertension (HTN) (OR 4.14, 95% CI 3.40-5.02, p=<0.001). The highest quartile of the triglyceride-glucose index was associated with a 4.14-fold increased odds of hypertension compared to the lowest quartile in adults without prior cardiovascular disease.
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