Key result
Manipulation of angiogenesis in the primate corpus luteum is predicted to profoundly influence the normal processes of follicular development, ovulation, and luteal function.
This review highlights the primate corpus luteum as a model for studying physiological angiogenesis and suggests that targeting angiogenic factors could modulate reproductive function.
Targeting luteal angiogenesis may modulate reproduction; leaves open safe clinical translation from primate models.
Intense physiological angiogenesis occurs during the early stages of luteal development, providing a model in which the complex processes regulating the angiogenic pathway may be studied. Here, a working hypothesis is presented to explain the diverse changes in the vasculature of the corpus luteum that occur over a short period, based around changes in vascular endothelial growth factor, the angiopoietins and matrix metalloproteinases. An illustration is given of how angiogenesis can be monitored in a primate model and how the role of individual angiogenic factors such as vascular endothelial growth factor may be explored in vivo. Because of the marked effect of inhibition of angiogenesis on luteal function, it is predicted that the normal processes of follicular development, ovulation and luteal function could all be profoundly influenced by the manipulation of angiogenesis.
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Fraser et al. (2001) conducted a review in Angiogenesis in the primate corpus luteum. Manipulation of angiogenesis was evaluated. Manipulation of angiogenesis in the primate corpus luteum is predicted to profoundly influence the normal processes of follicular development, ovulation, and luteal function.
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