Key result
Inflammatory factors and activated leukocytes play an important role in luteal angiogenesis during early luteal development.
Why the study?
Early luteal development involves an inflammatory response that may play an important role in luteal angiogenesis, but the specific role and mechanisms of inflammatory factors in this neovascularization needed review.
This review highlights the role of inflammatory responses and activated leukocytes in promoting angiogenesis during early luteal development.
Inflammatory leukocytes may drive luteal angiogenesis; hypothesis-generating without interventional data to guide practice.
Angiogenesis is a very important process that helps establish and maintain the normal structure and function of the corpus luteum (CL). Early luteal development can be considered a kind of physiological injury with an inflammatory response; therefore, the inflammatory response may play an important role in the luteal angiogenesis. The inflammatory response is companied by activated leukocytes and their mediators. For luteal tissue, numerous activated leukocytes such as macrophages, neutrophils and eosinophils are present in the early luteal phase and are widely involved in neovascularization. The objective of this review is to describe the role of the inflammatory factors in the angiogenesis and to discuss their mechanism. Knowledge of action and mechanism of these inflammatory factors on angiogenic activity will be beneficial for the understanding of luteal function.
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Lu et al. (2019) conducted a review in Luteal angiogenesis and inflammation. Inflammatory factors was evaluated. Inflammatory factors and activated leukocytes play an important role in luteal angiogenesis during early luteal development.
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