Key result
Among young women with myocardial infarction, 64% of oral contraceptive users lacked angiographic coronary atherosclerosis compared to 20.6% of non-users.
Why the study?
Does oral contraceptive use associate with the presence of coronary atherosclerosis in young women with myocardial infarction?
Population
76 female patients aged ≤50 years with a history of acute myocardial infarction.
Comparison
Oral contraceptive use vs No oral contraceptive use
Design
Cohort
Authors
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May suggest non-atherosclerotic MI mechanisms with OC use; leaves open need for prospective validation before practice implications.
Observational (n=76)
Does oral contraceptive use associate with the presence of coronary atherosclerosis in young women with myocardial infarction?
Absolute Event Rate: 64% vs 20.6%
Myocardial infarction in young women using oral contraceptives often occurs without underlying coronary atherosclerosis, suggesting a distinct non-atherogenic mechanism.
Engel et al. (1983) conducted an observational in Acute myocardial infarction (n=76). Oral contraceptives vs. No oral contraceptive use was evaluated on Absence of coronary atherosclerosis angiographically. Among young women with myocardial infarction, 64% of oral contraceptive users lacked angiographic coronary atherosclerosis compared to 20.6% of non-users.
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