Key result
Implantable cardioverter defibrillators reduce the risk of sudden cardiac death in patients with nonischemic cardiomyopathy, but do not significantly decrease long-term mortality because heart failure progression remains the primary cause of death.
Why the study?
Does implantable cardioverter defibrillator therapy reduce sudden cardiac death and overall mortality in patients with heart failure and nonischemic cardiomyopathy?
Does implantable cardioverter defibrillator therapy reduce sudden cardiac death and overall mortality in patients with heart failure and nonischemic cardiomyopathy?
Answers are grounded in this paper and cite their sources.
While ICDs reduce sudden cardiac death in nonischemic cardiomyopathy, they do not significantly improve long-term overall mortality because heart failure progression remains the primary cause of death.
tained ventricular the incidence of SCD was lower in the ICD group, there were no significant differences in mortality rates. The Comparison of Medical Therapy, Pacing, and Defibrillation in Heart Failure (COMPANION) trial compared resynchronization-pacemaker (CRT-P) and CRT with defibrillator (CRT-D) therapy, finding that that CRT-D significantly reduced the mortality rate. 4 However, in a subsequent meta-analysis by Long et al, CRT-D was non-superior to CRT-P in terms of overall deaths in NICM. 5 Thus, despite the many clinical trials that have been conducted, no reliable evidence has been obtained.
No takes yet. Share an insight, caveat, or question.
Toshiko Nakai (2023) conducted an editorial in Heart Failure and Nonischemic Cardiomyopathy. Implantable Cardioverter Defibrillator (ICD) vs. Medical therapy was evaluated. Implantable cardioverter defibrillators reduce the risk of sudden cardiac death in patients with nonischemic cardiomyopathy, but do not significantly decrease long-term mortality because heart failure progression remains the primary cause of death.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: