Key result
Pediatric orthostatic intolerance is linked to significantly lower quality of life scores versus healthy peers.
Why the study?
Orthostatic intolerance negatively impacts quality of life in children and adolescents, prompting an evaluation of how physical and psychosocial factors relate to their quality of life scores.
Cross-Sectional (n=95)
No
Absolute Event Rate: 50.7% vs 67.9%
p-value: p=<0.001
Children and adolescents with orthostatic intolerance experience significantly impaired quality of life across multiple domains, which is strongly associated with psychosocial factors such as school nonattendance.
QoL impairment in pediatric orthostatic intolerance associates with school nonattendance; leaves open whether psychosocial interventions improve outcomes.
BACKGROUND: Orthostatic intolerance (OI), which is common in children and adolescents, negatively impacts their quality of life (QOL) due to physical symptoms that limit work, school, and daily activities. The purpose of this study is to explore the association of physical and psychosocial factors with QOL scores in children and adolescents with OI. METHODS: A cross sectional observational study was conducted. The study participants included 95 Japanese pediatric patients of age 9-15 years who were diagnosed with OI from April 2010 to March 2020. The QOL scores and the QOL T-scores of children with OI assessed using the KINDL-R questionnaire at the initial visit were compared with conventional normative data. The associations of physical and psychosocial factors with the QOL T-scores were examined using multiple linear regression. RESULTS: Pediatric patients with OI had significantly lower QOL scores than healthy children in both elementary (50.7 ± 13.5 vs. 67.9 ± 13.4, p < 0.001) and junior high schools (51.8 ± 14.6 vs. 61.3 ± 12.6, p < 0.001). This finding was observed in the physical, mental, self-esteem, friends, and school domains. Total QOL scores were significantly associated with school nonattendance (β = - 3.2, 95% confidence interval [CI] = - 5.8 to - 0.5, p = 0.022) and poor relationship with school (β = - 5.0, 95% CI = - 9.8 to - 0.4, p = 0.035). CONCLUSIONS: These results suggest that the assessment of QOL, including both physical and psychosocial aspects, especially school factors, needs to be implemented earlier in children and adolescents with OI.
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Shigeyasu et al. (2023) conducted a cross-sectional in Orthostatic intolerance (n=95). Orthostatic intolerance vs. Healthy children was evaluated on Total QOL score in elementary school students (p=<0.001). Children and adolescents with orthostatic intolerance had significantly lower quality of life scores than healthy children in both elementary (50.7 vs 67.9) and junior high schools (51.8 vs 61.3).
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