Efferent sympathetic and vagal innervation of the canine right ventricle.
Key result
Efferent sympathetic fibers to the right ventricular outflow tract are located in both the subepicardium and subendocardium, while vagal fibers penetrate intramurally.
Population
Canine model
Design
Preclinical
Authors
Discussion
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Member takes
Implication
May inform autonomic targeting during RVOT ablation; extends LV innervation models but leaves open human translation.
Structured PICO
P
Population
Canine model
I
Intervention
Phenol and endocardial radiofrequency ablation applied to the right ventricular anterolateral wall and outflow tract
O
Outcome
Effective refractory period (ERP) shortening during bilateral ansae subclaviae stimulation and ERP lengthening during bilateral vagal stimulationsurrogate
Efferent sympathetic and vagal innervation of the right ventricle resembles the left ventricle, but sympathetic fibers to the right ventricular outflow tract are located in both the subepicardium and subendocardium.
Cite This Study
Ito et al. (1994) studied this question. Phenol and endocardial radiofrequency ablation was evaluated on Effective refractory period (ERP) shortening and lengthening during stimulation. Efferent sympathetic fibers to the right ventricular outflow tract are located in both the subepicardium and subendocardium, while vagal fibers penetrate intramurally.