Key result
Verapamil infusion reduced the number of exercise-induced premature ventricular complexes by 76±17% (P<0.05) compared to baseline in patients with CPVT and RyR2 mutations.
Why the study?
Do verapamil or magnesium infusions reduce exercise-induced ventricular arrhythmias in patients with CPVT and RyR2 mutations on beta-blocker therapy?
Do verapamil or magnesium infusions reduce exercise-induced ventricular arrhythmias in patients with CPVT and RyR2 mutations on beta-blocker therapy?
Effect estimate: 76+/-17% reduction
p-value: p=<0.05
Verapamil, but not magnesium, suppresses exercise-induced ventricular arrhythmias in CPVT patients with RyR2 mutations on background beta-blocker therapy.
No takes yet. Share an insight, caveat, or question.
Verapamil may reduce exercise-induced PVCs in RyR2-CPVT on beta-blockers; hypothesis-generating and requires randomized confirmation.
Swan et al. (2005) studied Catecholaminergic polymorphic ventricular tachycardia with RyR2 mutations (n=6). Verapamil and magnesium sulphate infusions vs. Baseline was evaluated on Number of isolated and successive premature ventricular complexes during exercise (76+/-17% reduction, p=<0.05). Verapamil infusion reduced the number of exercise-induced premature ventricular complexes by 76±17% (P<0.05) compared to baseline in patients with CPVT and RyR2 mutations.
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