Key result
Labor progression in a pregnant patient with Andersen-Tawil syndrome was associated with increased ventricular arrhythmias and sustained ventricular tachycardia.
Why the study?
Only three pregnant women with Andersen-Tawil syndrome had been reported, suggesting a low risk of arrhythmic events from pre-partum to delivery.
Case Report (n=1)
This case highlights that pregnant patients with Andersen-Tawil syndrome can experience severe exacerbation of ventricular arrhythmias during labor, potentially triggered by painful uterine contractions.
Answers are grounded in this paper and cite their sources.
Hypothesis-generating for arrhythmia risk during labor in Andersen-Tawil syndrome; prospective studies needed to guide management.
Andersen-Tawil syndrome (ATS) is a rare hereditary long QT syndrome type 7 caused by a missense mutation in the KCNJ2 gene. ATS is characterized by ventricular arrhythmia, periodic limb paralysis and minor external malformations. Although only three reports of pregnant women with Andersen-Tawil syndrome have been reported to date, no exacerbation of ventricular arrhythmia was observed from pre-partum to delivery in all cases compared to that before pregnancy, and it was suggested that the risk of arrhythmic events from pre-partum to delivery is not high. Unlike these previous reports, we herein present a case of Andersen-Tawil syndrome in which ventricular arrhythmias increased and sustained ventricular tachycardia was developed during labor progression. We also advise caution that pregnant patients with Andersen-Tawil syndrome may have varying times of exacerbation of the arrhythmia, and ventricular arrhythmias may be associated with painful uterine contractions.
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Inagaki et al. (2020) conducted a case report in Andersen-Tawil syndrome (n=1). Labor progression was evaluated on Exacerbation of ventricular arrhythmia. Labor progression in a pregnant patient with Andersen-Tawil syndrome was associated with increased ventricular arrhythmias and sustained ventricular tachycardia.
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