Key result
The combination of a beta-blocker and flecainide successfully suppressed ventricular arrhythmias in two pregnant patients with Andersen-Tawil syndrome when beta-blocker monotherapy failed.
Why the study?
Little is known about the physiologic effects of pregnancy on Andersen-Tawil syndrome and arrhythmia, and guidelines for peripartum or postpartum arrhythmia management are lacking.
Does the combination of beta-blocker and flecainide suppress ventricular arrhythmia in pregnant patients with Andersen-Tawil syndrome?
Population
Two KCNJ2-associated Andersen-Tawil syndrome patients who became pregnant
Design
Case report and literature review
Authors
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May support flecainide addition for refractory ventricular arrhythmias in pregnant Andersen-Tawil syndrome; hypothesis-generating, needs prospective confirmation.
Case Report (n=2)
No
Does the combination of beta-blocker and flecainide suppress ventricular arrhythmia in pregnant patients with Andersen-Tawil syndrome?
The combination of a beta-blocker and flecainide can effectively and safely suppress ventricular arrhythmias in pregnant patients with Andersen-Tawil syndrome when beta-blocker monotherapy fails.
Rujirachun et al. (2020) conducted a case report in Andersen-Tawil syndrome (n=2). Beta-blocker and flecainide combination vs. Beta-blocker monotherapy was evaluated on Suppression of ventricular arrhythmia. The combination of a beta-blocker and flecainide successfully suppressed ventricular arrhythmias in two pregnant patients with Andersen-Tawil syndrome when beta-blocker monotherapy failed.
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