Key result
Novel MKM2022 electromechanical model successfully reproduces experimental rate-dependent adaptation in human atrial cardiomyocytes.
Why the study?
Computational modelling is needed to accelerate the mechanistic understanding of complex mechano-electric regulations in human atrial cardiomyocytes.
Population
Mathematical model of human atrial cardiomyocytes
Design
Computational simulation study
Authors
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Advances in silico modeling of atrial electromechanics; leaves open experimental validation before informing arrhythmia mechanisms or therapies.
A novel computational model of human atrial cardiomyocytes successfully integrates electrophysiology and cardiomechanics to reproduce rate-dependent adaptation and mechanisms of alternans in atrial fibrillation.
Mazhar et al. (2023) studied Human atrial cardiomyocyte electrophysiology. MKM2022 electromechanical model vs. KM2011 model was evaluated on Rate adaptation of APD90, CaT, and active force. The novel MKM2022 electromechanical model successfully reproduced the experimentally observed rate-dependent adaptation of APD90, calcium transient, and active force in human atrial cardiomyocytes.
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