Key result
During ischemia, blood-perfused rabbit hearts exhibited a significantly larger mean calcium transient alternans ratio compared to saline-perfused hearts (0.23 vs 0.07, P=0.005).
Population
Rabbit hearts (blood- and saline-perfused)
Comparison
Ischemia produced by interruption of aortic… vs Saline-perfused hearts
Design
Preclinical
Authors
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Should not yet change clinical ischemia management; hypothesis-generating for blood factors in calcium alternans.
Absolute Event Rate: 0.23% vs 0.07%
p-value: p=0.005
Ischemia induces calcium transient alternans more frequently and severely in blood-perfused compared to saline-perfused rabbit hearts, which may relate to the development of ischemic arrhythmias.
Wu et al. (1997) studied Ischemia. Blood perfusion vs. Saline perfusion was evaluated on Mean alternans ratio during ischemia (p=0.005). During ischemia, blood-perfused rabbit hearts exhibited a significantly larger mean calcium transient alternans ratio compared to saline-perfused hearts (0.23 vs 0.07, P=0.005).
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