Population
20 dogs (intact beating hearts)
Comparison
Temperature lowering, verapamil, and caffeine vs Control conditions
Design
Preclinical
Authors
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Implicates delayed calcium cycling in electromechanical alternans in vivo; hypothesis-generating for human translation.
Delayed intracellular calcium cycling plays a key role in the concomitant occurrence of electrical and mechanical alternans in vivo.
Hirayama et al. (1993) studied this question.
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