January 1, 1991Acta Physiologica Scandinavica

Evidence for a link between mechanical and electrical alternans in acutely ischaemic myocardium of anaesthetized dogs

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Population

Anaesthetized dogs with acute myocardial ischaemia induced by acute coronary occlusion

Design

Preclinical

Authors

HHHisakuni HashimotoNihon Pharmaceutical University MNM NakashimaOgaki Municipal Hospital

Discussion

Member takes

Implication

Should not yet change ischemia management; hypothesis-generating for calcium-dependent alternans mechanisms in animal models.

Structured PICO

Population

Anaesthetized dogs with acute myocardial ischaemia induced by acute coronary occlusion

Intervention

Ventricular premature beat and calcium antagonists (verapamil and diltiazem)

Outcome

Effect on mechanical and electrical alternans (ST segment elevation and monophasic action potential repolarization)surrogate

Mechanical and electrical alternans in acute ischaemia are closely linked and inhibited by calcium antagonists, suggesting a shared calcium-dependent mechanism.

Cite This Study

Hashimoto et al. (1991) studied this question.

synapsesocial.com/papers/6a90401dccd91641af4dce88 https://doi.org/10.1111/j.1748-1716.1991.tb09045.x

View Full Paper

Ask AI

Bookmark

Evidence for a link between mechanical and electrical alternans in acutely ischaemic myocardium of anaesthetized dogs

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Evidence for a link between mechanical and electrical alternans in acutely ischaemic myocardium of anaesthetized dogs

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider