What question did this study set out to answer?

This research aims to investigate the occurrence of electrical alternans in the ST segment during myocardial ischemia.

January 1, 1978Japanese Heart JournalOpen Access

Experimental Studies and Clinical Report on the Electrical Alternans of ST Segment during Myocardial Ischemia

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Population

43 dogs with myocardial ischemia produced by occlusion of left coronary artery, and 1 clinical case

Design

Preclinical

Authors

MNMitsuyoshi NakashimaHamamatsu University School of Medicine HHHisakuni HashimotoNihon Pharmaceutical University MKMitsutaka KanamaruHamamatsu University School of Medicine

Discussion

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Implication

ST-T alternans may reflect ischemic repolarization changes; hypothesis-generating in dogs, clinical relevance remains undetermined.

Key Points

This research aims to investigate the occurrence of electrical alternans in the ST segment during myocardial ischemia.
Occlusion of the left coronary artery in 43 dogs to induce ischemia.
Simultaneous recording of surface and intracellular electrograms from ischemic areas.
Analysis of alternans in the ST-T complex and its relation to membrane action potential.
Electrical alternans was observed in 34 out of 43 experiments.
The alternans of ST segment corresponds to the repolarization of the membrane action potential.
Case report of electrical alternans changes in ST-T without QRS complex alterations.

Structured PICO

Population

43 dogs with myocardial ischemia produced by occlusion of left coronary artery, and 1 clinical case

Intervention

Occlusion of left coronary artery (experimental)

Outcome

Development of electrical alternans of ST-T complex and its correlation with membrane action potential repolarizationsurrogate

Electrical alternans of the ST-T complex during myocardial ischemia corresponds to alternations in the rate of repolarization of the membrane action potential.

Cite This Study

Nakashima et al. (1978) studied this question.

synapsesocial.com/papers/6a720c5ec2d7c30908272872 https://doi.org/10.1536/ihj.19.396

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Experimental Studies and Clinical Report on the Electrical Alternans of ST Segment during Myocardial Ischemia

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Experimental Studies and Clinical Report on the Electrical Alternans of ST Segment during Myocardial Ischemia

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

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