What question did this study set out to answer?

This research aims to explore the relationship between ST alternans and ventricular fibrillation during myocardial ischemia.

December 1, 1990Circulation

Significance of discordant ST alternans in ventricular fibrillation.

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Why the study?

Does the amplitude and discordance of ST alternans correlate with the occurrence of ventricular fibrillation during acute myocardial ischemia in dogs?

Population

8 dogs undergoing 7-minute occlusion of the left anterior descending coronary artery below its first…

Comparison

Epicardial mapping during acute myocardial… vs Dogs with resultant ventricular fibrillation…

Design

Preclinical

Follow-up

7 minutes

Authors

TKTsuneo KontaHeart Failure & Transplant KIK IkedaYamagata University MYMichiyasu YamakiYamagata University Hospital

Discussion

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Implication

Hypothesis-generating for ST alternans as VF marker in ischemia; human validation required before clinical consideration.

Key Points

This research aims to explore the relationship between ST alternans and ventricular fibrillation during myocardial ischemia.
Epicardial mapping was used to record electrograms in dogs during acute myocardial ischemia.
Sixty electrograms were recorded simultaneously at 1-minute intervals during 7 minutes of coronary artery occlusion.
Comparison of ST alternans amplitude was made between dogs with ventricular fibrillation and those without.
Dogs with ventricular fibrillation showed a greater ST alternans amplitude (3.92 +/- 1.24 mV) compared to those without (0.58 +/- 0.49 mV), p<0.05.
Three out of four dogs with ventricular fibrillation displayed discordant ST alternans, indicating electrical instability.
Findings suggest that discordant ST alternans could serve as potential indicators for ventricular repolarization instability.

Structured PICO

Does the amplitude and discordance of ST alternans correlate with the occurrence of ventricular fibrillation during acute myocardial ischemia in dogs?

Population

8 dogs undergoing 7-minute occlusion of the left anterior descending coronary artery below its first diagonal branch

Intervention

Epicardial mapping during acute myocardial ischemia induced by 7-minute LAD occlusion

Comparator

Dogs with resultant ventricular fibrillation (n=4) versus those without it (n=4)

Outcome

Amplitude and discordance of ST alternanssurrogate

Increased amplitude and discordance of ST alternans during acute myocardial ischemia are associated with ventricular fibrillation, serving as indicators of time and spatial unevenness of ventricular repolarization.

Cite This Study

Konta et al. (1990) studied this question.

synapsesocial.com/papers/6a1f718d2865985bbe2ad75f https://doi.org/10.1161/01.cir.82.6.2185

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Significance of discordant ST alternans in ventricular fibrillation.

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Significance of discordant ST alternans in ventricular fibrillation.

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

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