Key result
In permeabilized ventricular myocytes, glycolytic substrates were superior to mitochondrial substrates at suppressing ATP-sensitive K+ channels, reducing current to 34% versus 82% of control (p<0.004).
Population
Single guinea pig ventricular myocytes and isolated arterially perfused rabbit interventricular septa
Comparison
Glycolytic substrates, oxidative phosphorylation… vs Control conditions, individual glycolytic…
Design
Preclinical
Authors
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Does not yet alter clinical management of cardiac metabolism; leaves open preferential glycolytic ATP supply to KATP channels in vivo.
Absolute Event Rate: 34% vs 82%
p-value: p=<0.004
Key glycolytic enzymes appear to be physically associated with cardiac ATP-sensitive K+ channels, acting as a preferential source of ATP to regulate channel activity during high metabolic demand.
Weiss et al. (1989) studied Cardiac ATP-sensitive K+ channel regulation. Glycolytic substrates vs. Mitochondrial substrates was evaluated on Current through ATP-sensitive K+ channels (normalized to control) (p=<0.004). In permeabilized ventricular myocytes, glycolytic substrates were superior to mitochondrial substrates at suppressing ATP-sensitive K+ channels, reducing current to 34% versus 82% of control (p<0.004).
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