Key result
Glycolysis was more effective than oxidative phosphorylation in preventing ATP-sensitive K+ channels from opening in isolated guinea pig cardiac myocytes.
Why the study?
Does glycolysis preferentially inhibit ATP-sensitive K+ channels compared to oxidative phosphorylation in isolated guinea pig cardiac myocytes?
Population
Isolated guinea pig cardiac myocytes (permeabilized ventricular myocytes and excised inside-out patches)
Comparison
Glycolysis (as a source of ATP) vs Oxidative phosphorylation (as a source of ATP)
Design
Preclinical
Authors
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Does not alter ischemia management; leaves open whether glycolytic KATP preference translates to human myocardium.
Does glycolysis preferentially inhibit ATP-sensitive K+ channels compared to oxidative phosphorylation in isolated guinea pig cardiac myocytes?
Glycolysis is more effective than oxidative phosphorylation at inhibiting ATP-sensitive K+ channels in cardiac myocytes, highlighting a localized mechanism for ATP delivery to membrane channels that may be relevant during myocardial ischemia.
Weiss et al. (1987) studied Isolated guinea pig cardiac myocytes. Glycolysis vs. Oxidative phosphorylation was evaluated on Opening of ATP-sensitive K+ channels. Glycolysis was more effective than oxidative phosphorylation in preventing ATP-sensitive K+ channels from opening in isolated guinea pig cardiac myocytes.
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