Key result
Acute intravenous application of fluvastatin significantly reduced myocardial infarct size and attenuated the decline of myocardial blood flow and function in rats.
Why the study?
Does acute intravenous administration of fluvastatin reduce myocardial infarct size and attenuate reperfusion injury in a rat model of ischemia-reperfusion?
Does acute intravenous administration of fluvastatin reduce myocardial infarct size and attenuate reperfusion injury in a rat model of ischemia-reperfusion?
Acute intravenous administration of fluvastatin before ischemia reduces myocardial infarct size and attenuates reperfusion injury in a rat model, likely via inhibition of inflammation and endothelial dysfunction.
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Hypothesis-generating for acute statin pleiotropy in reperfusion; leaves open translation to human MI.
Tiefenbacher et al. (2003) studied Myocardial infarction and reperfusion injury. Fluvastatin vs. Control group was evaluated on Myocardial infarct size, myocardial blood flow, and regional myocardial function. Acute intravenous application of fluvastatin significantly reduced myocardial infarct size and attenuated the decline of myocardial blood flow and function in rats.
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