February 1, 1991Critical Care Medicine
Cardioprotective effects of authentic nitric oxide in myocardial ischemia with reperfusion
Why the study?
Does intravenous nitric oxide reduce myocardial necrosis in a feline model of ischemia and reperfusion?
Population
Open-chest, anesthetized cats in a 6-hr model of myocardial ischemia with reperfusion (LAD occlusion)
Comparison
Nitric oxide solution infused iv starting 30 min… vs Vehicle and Sodium nitrate (NaNO2)
Design
Preclinical
Follow-up
6 hours
Authors
Discussion
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Member takes
Implication
NO attenuates necrosis in feline MI; hypothesis-generating for human ischemia-reperfusion, should not yet change practice.
Structured PICO
Does intravenous nitric oxide reduce myocardial necrosis in a feline model of ischemia and reperfusion?
P
Population
Open-chest, anesthetized cats in a 6-hr model of myocardial ischemia with reperfusion (LAD occlusion)
I
Intervention
Nitric oxide (NO) solution infused iv starting 30 min after LAD occlusion, continuing through reperfusion 1 hr later, and lasting for 5.5 hr (estimated NO concentration 1 to 2 x 10(-9) M)
C
Comparator
Vehicle and Sodium nitrate (NaNO2)
O
Outcome
Necrotic area expressed as a percentage of the myocardial area-at-risksurrogate
Intravenous nitric oxide provides significant myocardial protection by reducing infarct size and neutrophil accumulation in a feline model of ischemia-reperfusion.
Cite This Study
Johnson et al. (1991) studied this question.