What question did this study set out to answer?

The study aims to investigate the levels of immunoreactive renin, prorenin, and active renin in plasma during pregnancy and in women using oral contraceptives.

October 1, 1986The Journal of Clinical Endocrinology & Metabolism

Immunoreactive Renin, Prorenin, and Enzymatically Active Renin in Plasma during Pregnancy and in Women Taking Oral Contraceptives*

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Why the study?

How do pregnancy and oral contraceptive use affect plasma levels of renin, prorenin, and renin substrate compared to normal women?

Population

142 women (44 pregnant women, 44 women taking an oral contraceptive, and 54 normal women)

Comparison

Pregnancy or oral contraceptive use vs Normal women

Design

Cross-sectional

Authors

FDF. H. M. DerkxGeneral / Preventive / Lipids CSCynthia A. StuenkelUniversity of California, San Diego MSM. P. A. SchalekampErasmus University Rotterdam

Discussion

Member takes

Implication

Should not yet change renin monitoring in pregnancy or OC users; leaves open causal effects on PRA and substrate.

Key Points

The study aims to investigate the levels of immunoreactive renin, prorenin, and active renin in plasma during pregnancy and in women using oral contraceptives.
Direct and indirect radioimmunoassays (RIA) were performed on plasma samples from 44 pregnant women, 44 women on oral contraceptives, and 54 normal women.
Parameters measured included immunoreactive renin, active renin, prorenin, plasma renin activity (PRA), and renin substrate.
Michaelis-Menten equations were used to compare calculated PRA values with measured results.
Immunoreactive renin was significantly higher in pregnant women (1090 pg/ml) compared to normal women (248 pg/ml, P<0.001) and lower in OC-treated women (131 pg/ml, P<0.001).
Both prorenin and active renin levels increased in pregnant women but decreased in OC-treated women.
PRA was elevated in pregnant women but normal in women taking oral contraceptives.

Structured PICO

How do pregnancy and oral contraceptive use affect plasma levels of renin, prorenin, and renin substrate compared to normal women?

Population

142 women (44 pregnant women, 44 women taking an oral contraceptive, and 54 normal women)

Intervention

Pregnancy or oral contraceptive use

Comparator

Normal women

Outcome

Plasma levels of immunoreactive renin, naturally occurring enzymatically active renin, trypsin-activatable inactive renin (prorenin), PRA, and renin substratesurrogate

Pregnancy increases and oral contraceptives decrease immunoreactive renin, while PRA remains normal during oral contraceptive treatment due to suppressed renal release of active renin compensating for increased renin substrate.

Cite This Study

Derkx et al. (1986) studied this question.

synapsesocial.com/papers/6a1f7ee1f84c8b0da9cf2bc2 https://doi.org/10.1210/jcem-63-4-1008

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October 1, 1986The Journal of Clinical Endocrinology & Metabolism

Immunoreactive Renin, Prorenin, and Enzymatically Active Renin in Plasma during Pregnancy and in Women Taking Oral Contraceptives*

View Full Paper

Ask AI

Bookmark

Why the study?

How do pregnancy and oral contraceptive use affect plasma levels of renin, prorenin, and renin substrate compared to normal women?

Population

142 women (44 pregnant women, 44 women taking an oral contraceptive, and 54 normal women)

Comparison

Pregnancy or oral contraceptive use vs Normal women

Design

Cross-sectional

Authors

FDF. H. M. DerkxGeneral / Preventive / Lipids CSCynthia A. StuenkelUniversity of California, San Diego MSM. P. A. SchalekampErasmus University Rotterdam

Discussion

Member takes

Implication

Should not yet change renin monitoring in pregnancy or OC users; leaves open causal effects on PRA and substrate.

Key Points

The study aims to investigate the levels of immunoreactive renin, prorenin, and active renin in plasma during pregnancy and in women using oral contraceptives.
Direct and indirect radioimmunoassays (RIA) were performed on plasma samples from 44 pregnant women, 44 women on oral contraceptives, and 54 normal women.
Parameters measured included immunoreactive renin, active renin, prorenin, plasma renin activity (PRA), and renin substrate.
Michaelis-Menten equations were used to compare calculated PRA values with measured results.
Immunoreactive renin was significantly higher in pregnant women (1090 pg/ml) compared to normal women (248 pg/ml, P<0.001) and lower in OC-treated women (131 pg/ml, P<0.001).
Both prorenin and active renin levels increased in pregnant women but decreased in OC-treated women.
PRA was elevated in pregnant women but normal in women taking oral contraceptives.

Structured PICO

How do pregnancy and oral contraceptive use affect plasma levels of renin, prorenin, and renin substrate compared to normal women?

Population

142 women (44 pregnant women, 44 women taking an oral contraceptive, and 54 normal women)

Intervention

Pregnancy or oral contraceptive use

Comparator

Normal women

Outcome

Plasma levels of immunoreactive renin, naturally occurring enzymatically active renin, trypsin-activatable inactive renin (prorenin), PRA, and renin substratesurrogate

Cite This Study

Derkx et al. (1986) studied this question.

synapsesocial.com/papers/6a1f7ee1f84c8b0da9cf2bc2 https://doi.org/10.1210/jcem-63-4-1008

Also Consider

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