Why the study?
Are active and total renin concentrations altered in women with severe pregnancy-associated hypertension compared to normotensive pregnant women?
Population
33 pregnant women, including 13 with severe pregnancy-associated hypertension and 20 normotensive pregnant…
Design
Case-control
Authors
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May indicate impaired renin activation in severe P-AH; leaves open diagnostic or therapeutic utility pending validation.
Are active and total renin concentrations altered in women with severe pregnancy-associated hypertension compared to normotensive pregnant women?
Severe pregnancy-associated hypertension is associated with low active renin levels but normal total renin levels, suggesting a failure in the secretion or activation of renin.
Nicholson et al. (1987) studied this question.
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