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August 1, 1975BJOG An International Journal of Obstetrics & Gynaecology

Changes in the Renin‐angiotensin System in Primigravidae With Hypertensive Disease of Pregnancy

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Population

35 primigravidae at or near term immediately prior to surgical induction of labour, including both…

Design

Cross-sectional

Authors

ESE. M. SymondsUniversiti Putra MalaysiaFPF. Rroughton PipkinUniversity of NottinghamDCD. J. CravenUniversity of Nottingham

Discussion

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Overview

Supports RAS role in term primigravidae hypertension; hypothesis-generating and should not yet change practice.

Key Points

  • To investigate the relationship between the renin-angiotensin system and hypertension in pregnant women who are experiencing their first pregnancy.
  • Measured plasma renin concentration, renin activity, and angiotensin II in 35 primigravidae at or near term.
  • Analyzed correlations between diastolic blood pressure and plasma angiotensin II levels.
  • Significant positive correlation between diastolic blood pressure and plasma angiotensin II levels.
  • In hypertensive women, negative relationship between plasma renin concentration, renin activity, and angiotensin II.
  • Higher plasma angiotensin II levels were observed in hypertensive women for given renin activity and concentration compared to normotensive women.

Structured PICO

P
Population
35 primigravidae at or near term immediately prior to surgical induction of labour, including both hypertensive and normotensive women
O
Outcome
Correlation between diastolic blood pressure and plasma angiotensin II, renin concentration, and renin activitysurrogate

The renin-angiotensin system is actively involved in hypertensive disease of pregnancy, with elevated angiotensin II levels potentially suppressing renin concentration and activity.

Cite This Study

Symonds et al. (1975) studied this question.

synapsesocial.com/papers/6a6ff536febe604dd708c5e8https://doi.org/10.1111/j.1471-0528.1975.tb00700.x
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Also Consider

Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Improved Assay Methods for Renin "Concentration" and "Activity" in Human Plasma1967 · 401 citations
  2. 2THE EFFECT OF BED REST ON PLASMA RENIN IN HYPERTENSIVE DISEASE OF PREGNANCY1974 · 22 citations
  3. 3Uterine blood flow and uterine renin secretion1972 · 105 citations
  4. 4PLASMA RENIN ACTIVITY IN PERIPHERAL AND UTERINE VEIN BLOOD IN PREGNANT AND NON‐PREGNANT WOMEN1972 · 34 citations