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November 1, 1978BJOG An International Journal of Obstetrics & Gynaecology

Sequential Changes in the Human Renin‐angiotensin System Following Delivery

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Population

10 patients following normal delivery, comprising 6 normotensive primigravidae and 4 mildly hypertensive…

Design

Cohort

Follow-up

four hours immediately following normal delivery

Authors

FPFiona Broughton PipkinUniversity of NottinghamJOJeremy OatsThe University of MelbourneESE. M. SymondsUniversiti Putra Malaysia

Discussion

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Overview

Postpartum renin-angiotensin shifts appear attenuated in mild hypertension; hypothesis-generating for peripartum physiology and requires prospective validation.

Structured PICO

P
Population
10 patients following normal delivery, comprising 6 normotensive primigravidae and 4 mildly hypertensive patients.
O
Outcome
Serial changes in plasma renin activity, renin concentration, and angiotensin II concentrationsurrogate

Following normal delivery, renin and angiotensin II levels initially fall sharply before rising again, suggesting clearance of fetoplacental renin followed by release from feedback suppression of renal renin synthesis.

Cite This Study

Pipkin et al. (1978) studied this question.

synapsesocial.com/papers/6a6ff536febe604dd708c5e7https://doi.org/10.1111/j.1471-0528.1978.tb15836.x
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Also Consider

Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1CHANGES IN THE RENIN‐ANGIOTENSIN SYSTEM IN PRIMIGRAVIDAE WITH HYPERTENSIVE DISEASE OF PREGNANCY1975 · 100 citations
  2. 2Factors affecting angiotensin II concentrations in the human infant at birth1977 · 92 citations
  3. 3PLASMA RENIN ACTIVITY IN PERIPHERAL AND UTERINE VEIN BLOOD IN PREGNANT AND NON‐PREGNANT WOMEN1972 · 34 citations
  4. 4Disappearance Rate of Endogenous Renin from the Plasma After Bilateral Nephrectomy in Humans1969 · 22 citations