Why the study?
Does the combination of linezolid, amitriptyline, and fentanyl cause serotonin syndrome?
Does the combination of linezolid, amitriptyline, and fentanyl cause serotonin syndrome?
Highlights the risk of serotonin syndrome when combining linezolid with amitriptyline and fentanyl.
Urges vigilance for serotonin syndrome with this combination; hypothesis-generating case report that leaves open need for confirmatory data.
We report a unique case of an adverse interaction between the oxazolidinone antibiotic linezolid, the tricyclic antidepressant amitriptyline and the opioid analgesic fentanyl in a 68-year-old woman with advanced ischemic peripheral arterial disease and sepsis, under empirical antibiotic treatment. We also summarize the current relevant literature as identified via PubMed, EMBASE, and PsycINFO as well as reference sections of selected articles.
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Samartzis et al. (2013) studied this question.
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