Key result
Among 72 patients receiving linezolid and an SSRI or venlafaxine within 14 days, only 2 (3%) developed a high probability of serotonin syndrome.
Why the study?
Does concomitant use of linezolid and SSRIs cause serotonin syndrome in inpatients?
Population
72 inpatients at the Mayo Clinic with concomitant orders or therapy within 14 days for linezolid and an SSRI…
Design
Cohort
Authors
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Coadministration may be feasible with monitoring rather than avoidance; leaves open need for larger prospective confirmation.
Observational (n=72)
No
Does concomitant use of linezolid and SSRIs cause serotonin syndrome in inpatients?
Concomitant use of linezolid and SSRIs is associated with a low incidence (3%) of serotonin syndrome, suggesting they may be used together with careful monitoring.
Taylor et al. (2006) conducted an observational in Patients receiving linezolid and an SSRI or venlafaxine (n=72). Concomitant linezolid and SSRI or venlafaxine was evaluated on Incidence of serotonin syndrome. Among 72 patients receiving linezolid and an SSRI or venlafaxine within 14 days, only 2 (3%) developed a high probability of serotonin syndrome.
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