Key result
Concurrent use of linezolid and serotonergic medications, most commonly SSRIs, was associated with 29 reported cases of serotonin toxicity in the FDA Adverse Event Reporting System.
Why the study?
Does the concurrent use of linezolid and serotonergic drugs result in serotonin toxicity?
Population
29 cases of serotonin toxicity reported to the US FDA Adverse Event Reporting System, ages 17-83 years, 1:1…
Design
Case_series
Authors
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May warrant vigilance with linezolid plus SSRIs; hypothesis-generating FAERS data leave causality and incidence open.
Does the concurrent use of linezolid and serotonergic drugs result in serotonin toxicity?
Concurrent use of linezolid with serotonergic medications, particularly SSRIs, can result in severe serotonin toxicity requiring intervention or hospitalization.
Lawrence et al. (2006) conducted a review in Serotonin toxicity (n=29). Linezolid with concurrent serotonergic drugs was evaluated on Serotonin toxicity. Concurrent use of linezolid and serotonergic medications, most commonly SSRIs, was associated with 29 reported cases of serotonin toxicity in the FDA Adverse Event Reporting System.
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