Key result
Linezolid linked to rapidly reversible serotonin syndrome in a 72-year-old man.
Why the study?
Linezolid, widely used in hospitals, may cause serotonin syndrome even without concomitant use of serotonin agonists, but such cases are rarely reported.
Population
A 72-year-old patient with recurrent MRSA wound infection
Comparison
Linezolid exposure without serotonin agonists
Design
Case report
Follow-up
2 days after linezolid discontinuation
Authors
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Linezolid may trigger serotonin syndrome without other serotonergic drugs; this case leaves open questions on incidence and risk factors.
Case Report (n=1)
No
Linezolid can cause life-threatening serotonin syndrome even in the absence of concomitant serotonin agonist use.
Jeon et al. (2014) conducted a case report in Serotonin syndrome (n=1). Linezolid was evaluated on Development of serotonin syndrome. A 72-year-old man developed serotonin syndrome after being treated with linezolid for an MRSA infection, which fully recovered within 2 days of discontinuing the drug.
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